Anti-Phenytoin (Dilantin)

Phenytoin is an anticonvulsant drug which can be useful in the treatment of epilepsy. Phenytoin blocks voltage-sensitive sodium channels in neurons. This action leads to a delay in neuronal electrical recovery. Phenytoin's inhibitory effect is dependent on the voltage and frequency of neural cell firing by selectively blocking the neurons that are firing at high frequency. Phenytoin prevents the electrical spread of a focus of irritable tissue from entering normal tissue. Phenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic clonic (grand mal) seizures. Applications: Suitable for use in RIA, ELISA and Immunofluorescence. Other applications not tested. Recommended Dilutions: Optimal dilution determined by the researcher. Titer: RIA: 110,000 test/ml @65% Binding, Sensitivity: 4ug/ml at ED50, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.