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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with... more
Product information "Anti-PELI1"
PELI1 (Pellino E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with PELI1 include Tyrosinemia, Type Iii. Among its related pathways are Diseases associated with the TLR signaling cascade and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PELI2. Protein function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation, preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609). Negatively regulates necroptosis by reducing RIPK3 expression (PubMed:29883609). Mediates 'Lys-63'-linked ubiquitination of RIPK1 (PubMed:29883609). [The UniProt Consortium]
Keywords: | Anti-PELI1, Anti-PRISM, Anti-Pellino-1, Anti-E3 ubiquitin-protein ligase pellino homolog 1, Anti-Pellino-related intracellular-signaling molecule, Anti-RING-type E3 ubiquitin transferase pellino homolog 1, PELI1 Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-67967 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | rat |
Immunogen: | Recombinant fusion protein of human PELI1 (NP_065702.2). |
Database Information
KEGG ID : | K11964 | Matching products |
UniProt ID : | Q96FA3 | Matching products |
Gene ID | GeneID 57162 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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