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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG42967.50 | 50 µg | - | - |
6 - 14 business days* |
520.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Calcium-binding protein that acts as an adapter that bridges unrelated proteins... more
Product information "Anti-PEF1 / Peflin"
Protein function: Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats (PubMed:27716508). In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (PubMed:27716508). Its role in the heterodimer formed with PDCD6 is however unclear: some evidence shows that PEF1 and PDCD6 work together and promote association between PDCD6 and SEC31 in presence of calcium (PubMed:27716508). Other reports show that PEF1 dissociates from PDCD6 in presence of calcium, and may act as a negative regulator of PDCD6 (PubMed:11278427). Also acts as a negative regulator of ER-Golgi transport, possibly by inhibiting interaction between PDCD6 and SEC31. [The UniProt Consortium]
Keywords: | Anti-ABP32, Anti-Peflin, Anti-Peflin, Anti-Penta-EF hand domain-containing protein 1, Anti-Penta-EF hand domain-containing protein 1, Anti-PEF protein with a long N-terminal hydrophobic domain, Anti-PEF protein with a long N-terminal hydrophobic domain |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG42967 |
Properties
Application: | IHC (paraffin), WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant protein corresponding to R170-L284 of Human PEF1 / Peflin |
MW: | 30 kD |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K23905 | Matching products |
UniProt ID : | Q9UBV8 | Matching products |
Gene ID | GeneID 553115 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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