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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES14195.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES14195.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes... more
Product information "Anti-PCSK6"
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014], Protein function: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: [Isoform PACE4A-I]: Secreted., [Isoform PACE4A-II]: Secreted., [Isoform PACE4C]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum., [Isoform PACE4CS]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum., [Isoform PACE4E-I]: Endomembrane system, Peripheral membrane protein. Retained intracellularly probably through a hydrophobic cluster in their C-terminus., [Isoform PACE4E-II]: Endomembrane system, Peripheral membrane protein. Retained intracellularly probably through a hydrophobic cluster in their C-terminus., [Isoform PACE4B]: Secreted.
Keywords: | Anti-SPC4, Anti-PACE4, Anti-PCSK6, EC=3.4.21.-, Anti-Subtilisin/kexin-like protease PACE4, Anti-Subtilisin-like proprotein convertase 4, Anti-Paired basic amino acid cleaving enzyme 4, Anti-Proprotein convertase subtilisin/kexin type 6, PCSK6 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES14195 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat |
Immunogen: | Synthesized peptide derived from human PCSK6 AA range: 734-784 |
MW: | 105 kD |
Format: | Purified |
Database Information
KEGG ID : | K08672 | Matching products |
UniProt ID : | P29122 | Matching products |
Gene ID | GeneID 5046 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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