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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES14196.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES14196.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes... more
Product information "Anti-PCSK5"
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014], Protein function: Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000,IHC-p 1:50-300, ELISA 2000-20000. Cellular localization: [Isoform PC6A]: Secreted. Secreted through the regulated secretory pathway. ., [Isoform PC6B]: Endomembrane system, Single-pass type I membrane protein. Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes. .
Keywords: | Anti-PC6, Anti-PC5, Anti-hPC6, Anti-PCSK5, EC=3.4.21.-, Anti-Proprotein convertase 5, Anti-Proprotein convertase 6, Anti-Subtilisin/kexin-like protease PC5, Anti-Proprotein convertase subtilisin/kexin type 5, PCSK5 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES14196 |
Properties
Application: | WB, ELISA, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthesized peptide derived from human PCSK5 AA range: 1507-1557 |
Format: | Purified |
Database Information
KEGG ID : | K08654 | Matching products |
UniProt ID : | Q92824 | Matching products |
Gene ID | GeneID 5125 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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