Anti-PCNA (IHC)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00012-T 10 µl (1 µg) -

2 - 8 business days*

164.00€
IHC-00012 100 µl (10 µg) -

2 - 8 business days*

623.00€
 
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of... more
Product information "Anti-PCNA (IHC)"
Protein function: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'- 5' exonuclease and 3'-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. [The UniProt Consortium]
Keywords: Anti-PCNA, Anti-Cyclin, Anti-Proliferating cell nuclear antigen
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00012

Properties

Application: IHC, IHC-IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, sheep, bovine, dog, rabbit, guinea pig, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, chinese hamster, naked mole rat, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00012 maps to a region between residue 225 and the C-terminus (residue 261) of human proliferating cell nuclear antigen using the numbering given in entry NP 002583.1 (GeneID 5111).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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