Anti-PAPP-A / Pappalysin-1 (Marker of Atherosclerosis and Aneuploid Fetus) Monoclonal Antibody (Clon

Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, althoµgh it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thoµght to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been sµggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been sµggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD). Protein function: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. [The UniProt Consortium]