Anti-PAN2/USP52

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A304-882A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A304-882A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of... more

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Product information "Anti-PAN2/USP52"

Protein function: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. [The UniProt Consortium]

Keywords:	Anti-KIAA0710, Anti-PAN deadenylation complex subunit 2, Anti-PAB1P-dependent poly(A)-specific ribonuclease, Anti-Poly(A)-nuclease deadenylation complex subunit 2, Anti-Inactive ubiquitin carboxyl-terminal hydrolase 52
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-882A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: rat)
Immunogen:	synthetic peptide. The epitope recognized by A304-882A-T maps to a region between residue 1 to 50 of human PAB-dependent poly using the numbering given in entry Q504Q3.3 (GeneID 9924).
Format:	Antigen Affinity Purified