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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| ARG43886.50 | 50 µg | - | - |
6 - 14 business days* |
520.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of... more
Product information "Anti-PAN2"
Protein function: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation. [The UniProt Consortium]
| Keywords: | Anti-KIAA0710, Anti-PAN deadenylation complex subunit 2, Anti-PAN deadenylation complex subunit 2, Anti-PAB1P-dependent poly(A)-specific ribonuclease, Anti-PAB1P-dependent poly(A)-specific ribonuclease, Anti-Poly(A)-nuclease deadenylation complex subunit |
| Supplier: | Arigo Biolaboratories |
| Supplier-Nr: | ARG43886 |
Properties
| Application: | ELISA, FC, WB |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
| Immunogen: | Human PAN2 recombinant protein |
| MW: | 135 kD |
Database Information
| KEGG ID : | K12571 | Matching products |
| UniProt ID : | Q504Q3 | Matching products |
| Gene ID | GeneID 9924 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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