Anti-PAF Receptor (human) (11A4, Clone 21)

PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling. Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain. In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor. Human monocytes treated with INF-gamma have a 2-6 fold increase in PAF receptor expression compared to untreated cells.Synonyms: Platelet-activating Factor Receptor. Immunogen: Synthetic peptide from the internal region of human PAF receptor. Clone Designation: 11A4, Clone 21. Formulation: (Request formulation change), 100 µg of protein A-purified monoclonal antibody. Storage Buffer: TBS, pH 7.4, when reconstituted in 500 µl of deionized water. Host: Mouse. Isotype: IgG2a. Applications: (+) ELISA, FC, and ICC, (-) WB. UniProt Accession #: P25105. Origin: Animal/Mouse.