Anti-PACT

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
MM-0228-P	50 µg		-	-	3 - 8 business days*		386.00€

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Protein function: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to... more

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Product information "Anti-PACT"

Protein function: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post- transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner. [The UniProt Consortium]

Keywords:	Anti-PACT, Anti-PRKRA, Anti-HSD-14, Anti-PKR-associated protein X, Anti-PKR-associating protein X, Anti-Protein activator of the interferon-induced protein kinase, Anti-Protein kinase, interferon-inducible double-stranded RNA-dependent activator
Supplier:	MediMabs
Supplier-Nr:	MM-0228-P

Properties

Application:	WB, IP, IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Format:	Purified

Database Information

KEGG ID :	K24540 \| Matching products
UniProt ID :	O75569 \| Matching products
Gene ID	GeneID 8575 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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