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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
100-401-A10 | 100 µl | - | - |
6 - 10 business days* |
684.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding... more
Product information "Anti-p48DDB2, CT"
Protein function: Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1- CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4- ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair. [The UniProt Consortium]
Keywords: | Anti-DDBb, Anti-DDB2, Anti-UV-DDB 2, Anti-DDB p48 subunit, Anti-DNA damage-binding protein 2, Anti-UV-damaged DNA-binding protein 2, Anti-Damage-specific DNA-binding protein 2 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 100-401-A10 |
Properties
Application: | ELISA, IHC, IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | synthetic peptide corresponding to amino acids 419-427 of human DDB2 (C-terminal) |
MW: | 48 kD |
Format: | Serum |
Database Information
KEGG ID : | K10140 | Matching products |
UniProt ID : | Q92466 | Matching products |
Gene ID | GeneID 1643 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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