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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-1230-100 | 100 µg | - |
3 - 11 business days* |
850.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb... more
Product information "Anti-p21WAF1 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (clone:CIP1/2275R)"
This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma). Protein function: May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). [The UniProt Consortium]
Keywords: | Anti-p21, Anti-MDA-6, Anti-CAP20, Anti-CDKN1A, Anti-CDK-interacting protein 1, Anti-Cyclin-dependent kinase inhibitor 1, Anti-Melanoma differentiation-associated protein 6, Anti-p21WAF1 (Tumor Suppressor Protein) Recombinant Rabbit Monoclonal Antibody (Cl |
Supplier: | Abeomics |
Supplier-Nr: | 12-1230 |
Properties
Application: | IHC |
Antibody Type: | Monoclonal |
Clone: | CIP1/2275R |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant full-length human CDKN1A protein |
Format: | Purified |
Database Information
KEGG ID : | K06625 | Matching products |
UniProt ID : | P38936 | Matching products |
Gene ID | GeneID 1026 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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