Anti-p21, clone SPM306

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG56160.50	50 µg		-	-	6 - 14 business days*		608.00€

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Protein function: May be the important intermediate by which p53/TP53 mediates its role as an... more

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Product information "Anti-p21, clone SPM306"

Protein function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. [The UniProt Consortium]

Keywords:	Anti-p21, Anti-CAP20, Anti-MDA-6, Anti-CDKN1A, Anti-CDK-interacting protein 1, Anti-Cyclin-dependent kinase inhibitor 1, Anti-Melanoma differentiation-associated protein 6
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG56160

Properties

Application:	FC, ICC, IF, IHC (paraffin), WB
Antibody Type:	Monoclonal
Clone:	SPM306
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	Human recombinant p21 protein
MW:	21 kD
Format:	Purified