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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
200-501-891 | 100 µg | - | - |
6 - 10 business days* |
698.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor... more
Product information "Anti-p19ARF (exon 1b), clone 5-C3-1"
Protein function: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. [The UniProt Consortium]
Keywords: | Anti-p19ARF, Anti-Cdkn2a, Anti-Cyclin-dependent kinase inhibitor 2A, isoform 3 |
Supplier: | Rockland Immunochemicals |
Supplier-Nr: | 200-501-891 |
Properties
Application: | ELISA, IFM, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 5-C3-1 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Immunogen: | synthetic peptide corresponding to amino acids 54-75 of mouse p19 Arf protein |
MW: | 19 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06621 | Matching products |
UniProt ID : | Q64364 | Matching products |
Gene ID | GeneID 12578 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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