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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V7991-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V7991-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. 8-oxoguanine (8-oxoG), an oxidized... more
Product information "Anti-OGG1, clone CPTC-OGG1-1"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. 8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversionmutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Guanine is the main target for reactive oxygen species in DNA, and 8-oxoguanine is the most frequent base lesion. Therefore, formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Furthermore, defects in OGG1 may be a cause of renal cell carcinoma. Protein function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. [The UniProt Consortium]
Keywords: | Anti-MMH, Anti-OGG1, Anti-AP lyase, EC=3.2.2.-, EC=4.2.99.18, Anti-N-glycosylase/DNA lyase, Anti-8-oxoguanine DNA glycosylase, Anti-DNA-(apurinic or apyrimidinic site) lyase, OGG1 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V7991 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | CPTC-OGG1-1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant full-length human protein |
Format: | Purified |
Database Information
KEGG ID : | K03660 | Matching products |
UniProt ID : | O15527 | Matching products |
Gene ID | GeneID 4968 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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