Anti-NR5A1 / SF1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG59816.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Transcriptional activator. Essential for sexual differentiation and formation... more

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Product information "Anti-NR5A1 / SF1"

Protein function: Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'- RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. [The UniProt Consortium]

Keywords:	Anti-SF-1, Anti-NR5A1, Anti-STF-1, Anti-AD4BP, Anti-hSF-1, Anti-Steroidogenic factor 1, Anti-Adrenal 4-binding protein, Anti-Fushi tarazu factor homolog 1, Anti-Steroid hormone receptor Ad4BP, Anti-Nuclear receptor subfamily 5 group A member 1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG59816

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	mouse, rat
Immunogen:	Recombinant fusion protein corresponding to aa. 1-120 of Human NR5A1 / SF1 (NP_004950.2)
MW:	51 kD
Format:	Affinity Purified