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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene is a transcriptional activator involved in sex determination.... more
Product information "Anti-NR5A1"
The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. Protein function: Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues (PubMed:27378692). Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'- RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1 (PubMed:27378692). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. Binds phosphatidylcholine. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. [The UniProt Consortium]
Keywords: | Anti-SF-1, Anti-hSF-1, Anti-NR5A1, Anti-AD4BP, Anti-STF-1, Anti-Steroidogenic factor 1, Anti-Adrenal 4-binding protein, Anti-Fushi tarazu factor homolog 1, Anti-Steroid hormone receptor Ad4BP, Anti-Nuclear receptor subfamily 5 group A member 1, NR5A1 Poly |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-65374 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, rat |
Immunogen: | Recombinant protein of human NR5A1 |
Database Information
KEGG ID : | K08560 | Matching products |
UniProt ID : | Q13285 | Matching products |
Gene ID | GeneID 2516 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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