Anti-NPLOC4

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG43152.100 100 µl - -

6 - 14 business days*

624.00€
 
Protein function: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated... more
Product information "Anti-NPLOC4"
Protein function: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). [The UniProt Consortium]
Keywords: Anti-NPLOC4, Anti-KIAA1499, Anti-Protein NPL4, Anti-Protein NPL4, Anti-Nuclear protein localization protein 4 homolog, Anti-Nuclear protein localization protein 4 homolog
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG43152

Properties

Application: ICC, IF, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat)
Immunogen: Recombinant fusion protein corresponding to aa. 1-270 of Human NPLOC4 (NP_060391.2)
MW: 68 kD
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: °C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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