Anti-Nod2

Nod2 is a member of a protein family of apoptosis regulators which includes Apaf-1 and Nod1/CARD4. Nod2 contains two N-terminal caspase recruitment domains (CARDs), a nucleotide binding domain (NBD) and C-terminal leucine rich repeats (LRRs). Nod1/CARD4 is broadly expressed in tissues, however, Nod2 expression is limited to monocytes. Both Nod1 and Nod2 activate NF-kB and act as intracellular receptors for bacterial lipopolysaccharides (LPS). The LRRs of both Nod1 and Nod2 are essential for LPS-induced activation of NF-kB. A frameshift mutation in the NOD2 gene confers susceptibility to Crohn's disease, possibly by causing truncation of the 10th LRR resulting in a protein that is unresponsive to LPS.Synonyms: Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, Nucleotide-binding oligomerization domain-containing protein 2. Immunogen: Recombinant protein fragment from the internal region of human Nod2. Formulation: (Request formulation change), 100 µg of protein A purified antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1% BSA, and 0.02% sodium azide. Host: Rabbit. Applications: WB. UniProt Accession #: Q9HC29. Origin: Animal/Rabbit.