Anti-NO66

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-198A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A303-198A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal... more

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Product information "Anti-NO66"

Protein function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC- induced transcriptional activation. [The UniProt Consortium]

Keywords:	Anti-ROX, Anti-NO66, Anti-hsNO66, Anti-C14orf169, EC=1.14.11.-, EC=1.14.11.27, Anti-Nucleolar protein 66, Anti-Ribosomal oxygenase NO66, Anti-Histone lysine demethylase NO66, Anti-Myc-associated protein with JmjC domain
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-198A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: rhesus monkey, gorilla)
Immunogen:	synthetic peptide. The epitope recognized by A303-198A-T maps to a region between residue 1 and 50 of human Nucleolar Protein 66 using the numbering given in entry NP_078920.2 (GeneID 79697).
Format:	Antigen Affinity Purified