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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-20B-0067-C100 | 100 µg | - |
3 - 9 business days* |
424.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation... more
Product information "Anti-NLRC3 (mouse), clone Eowyn-1"
The novel nucleotide oligomerization domain (NOD)-like receptor (NLR) with a caspase activation and recruitment domain (CARD) 3 (NLRC3) protein belongs to the NLR family of cytosolic pathogen recognition receptors. NLRC3 has the characteristic NOD and leucine-rich repeat configuration with a less well defined CARD. NLRC3 is expressed in T lymphocytes and may be involved in suppression of T cell activation. NLRC3 is a cytoplasmic protein that negatively regulates pro-IL-1beta maturation and inhibits toll-like receptor (TLR)-dependent activation of the transcription factor NF-kappaB. NLRC3 interacts with the TLR signaling adaptor TRAF6 to attenuate Lys63 (K63)-linked ubiquitination of TRAF6 and activation of NF-kappaB. NLRC3 also reduces STING-dependent innate immune activation in response to cytosolic DNA, cyclic di-GMP (c-di-GMP) and DNA viruses. NLRC3 associated with both STING and TBK1, impedes STING-TBK1 interaction and downstream type I interferon production.
Keywords: | Anti-Nlrc3, Anti-Protein NLRC3, Anti-NOD3, Anti-Nucleotide-binding Oligomerization Protein 3, Anti-CARD15-like Protein, Anti-Caterpiller Protein 16.2, Anti-CLR16.2 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-20B-0067 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | Eowyn-1 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | mouse |
Immunogen: | recombinant mouse NLRC3 (card domain) |
Purity: | >95% |
Format: | Purified |
Database Information
UniProt ID : | Q5DU56 | Matching products |
Gene ID | GeneID 268857 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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