Anti-NFAT2 / NFATC1

Anti-NFAT2 / NFATC1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ5535 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. NFATC1 (Nuclear factor of activated... more
Product information "Anti-NFAT2 / NFATC1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. NFATC1 (Nuclear factor of activated T-cells, cytoplasmic 1), also known as NFATC or NFAT2, is a protein that in humans is encoded by the NFATC1 gene. And it is also a component of the nuclear factor of activated T cells DNA-binding transcription complex. The NFATC1 gene is mapped on 18q23. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. NFATC1 was not detected in brain, liver, or kidney. NFATC1 is an inducible nuclear component which functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. The solution structure of the binary complex formed between the core DNA-binding domain of human NFATC1 and the 12-bp oligonucleotide duplex containing the ARRE2 DNA site from the IL2 promoter. Nfatc1 was expressed exclusively in mouse hair follicle stem cells, and using gain- and loss-of-function approaches, and Nfatc1 inhibited stem cell activation. Protein function: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. [The UniProt Consortium]
Keywords: Anti-NFATc, Anti-NFAT2, Anti-NFATc1, Anti-NFATC1, Anti-NF-ATc, Anti-NF-ATc1, Anti-NFAT transcription complex cytosolic component, Anti-Nuclear factor of activated T-cells, cytoplasmic 1, NFAT2 Antibody / NFATC1
Supplier: NSJ Bioreagents
Supplier-Nr: RQ5535

Properties

Application: WB, Direct ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A human recombinant protein (amino acids F374-E710)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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