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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29265-100 | 100 µl | - |
6 - 10 business days* |
457.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NeuN, also known as FOX3 and RNA binding protein fox-1 homolog 3 (Rbfox3), is a pre-mRNA... more
Product information "Anti-NeuN Monoclonal Antibody (Clone 1B7)"
NeuN, also known as FOX3 and RNA binding protein fox-1 homolog 3 (Rbfox3), is a pre-mRNA alternative splicing regulator encoded by RBFOX3 in humans. It is expressed in mature neurons of the brain and spinal cord and is commonly used as a neuronal marker to quantify the number of new neurons generated during adult neurogenesis or the extent of therapeutic neuroprotection in animal models of neurodegenerative disease. There are two subtypes of NeuN, a 46 kDa nuclear form and 48 kDa cytoplasmic form. Cytosolic NeuN is increased in the lumbar spinal cord in a mouse model of amyotrophic lateral sclerosis (ALS) compared with control animals. Exon deletions and truncations of NeuN are found in patients with Rolandic epilepsy and RBFOX3 is located within the apparently balanced chromosomal rearrangement (ABCR) regions of chromosomes in patients with developmental delays and speech disorders. Cayman's NeuN Monoclonal Antibody (Clone 1B7) can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes nuclear and cytosolic NeuN at approximately 46 and 48 kDa, respectively.Synonyms: FOX3, Rbfox3, RNA Binding Protein Fox-1 Homolog 3. Immunogen: Recombinant protein from the N-terminus of human NeuN. Clone Designation: 1B7. MW: 46 and 48 kDa for nuclear and cytosolic NeuN, respectively. Formulation: (Request formulation change), 100 µl of Protein G-purified mouse monoclonal antibody. Storage Buffer: PBS with 50% glycerol and 5 mM sodium azide. Host: Mouse. Isotype: IgG2a. Applications: ICC, IHC, and WB.
Keywords: | FOX3, Rbfox3, RNA Binding Protein Fox-1 Homolog 3 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29265 |
Properties
Application: | ICC, IHC, WB |
Antibody Type: | Monoclonal |
Clone: | 1B7 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, bovine, mouse, rat |
Immunogen: | Recombinant protein from the N-terminus of human NeuN |
Format: | Purified |
Database Information
KEGG ID : | K14946 | Matching products |
UniProt ID : | A6NFN3 | Matching products |
Gene ID | GeneID 146713 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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