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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
366972.100 | 100 µg | - | - |
3 - 19 business days* |
780.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Contactin-5 (UniProt P68500, also known as Neural recognition molecule NB-2) is encoded by the... more
Product information "Anti-NB-2 (Contactin-5, Cntn5, Neural Recognition Molecule NB-2)"
Contactin-5 (UniProt P68500, also known as Neural recognition molecule NB-2) is encoded by the Cntn5 gene (Gene ID 244682) in murine species. Contactin-5 (NB-2) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein belonging to a subgroup of the immunoglobulin superfamily of proteins known as contactins. Five of the six contactins, Contactin-1, contactin-2/TAG-1, contactin-3/BIG-1, contactin-4/BIG-2, and contactin-5/NB-2 are expressed by DRG neurons. Of these, contactin-1, TAG-1, and BIG-2, are also expressed by motor neurons. NB-2 plays an important role in synapse formation in the developing auditory system in rodents. Expression of NB-2 is seen in the central auditory pathways just before the onset of hearing in rodents and is localized at glutamatergic synapses in the postnatal auditory brainstem. NB-2-knockout mice exhibit abnormal responses to auditory stimuli in both neuronal excitability and behavior, and have delayed auditory brainstem response waves. In addition, NB-2 deficiency in mice causes a significant reduction in the number of synapses and induces apoptosis in a subset of neurons in the auditory brainstem. NB-2 is produced with an N-terminal signal peptide (aa1-23) and a C-terminal propeptide (aa1072-1098) sequence, the removal of which yields the mature GPI-anchored glycoprotein (aa24-1071) with six C2-type Ig-like domains (aa98-659) and four type-III fibronectin domains (aa672-1066). Applications: Suitable for use in Immunofluorescence, Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2ug/mL detects NB-2 in postnatal P14 and adult mouse brain tissue lysates., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Cntn5, Anti-Contactin-5, Anti-Neural recognition molecule NB-2 |
Supplier: | United States Biological |
Supplier-Nr: | 366972 |
Properties
Application: | ICC, IF, WB |
Antibody Type: | Monoclonal |
Clone: | 1A6 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | mouse |
Immunogen: | Recombinant protein corresponding to mouse NB-2/Cntn5, human IgG Fc-tagged. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06763 | Matching products |
UniProt ID : | P68500 | Matching products |
Gene ID | GeneID 244682 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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