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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
N0018-60J1.100 | 100 µg | - | - |
3 - 19 business days* |
962.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
NALP1 is a 160-170kD member of the NLRP family of molecules. It is expressed in dendritic cells,... more
Product information "Anti-NALP1 (NACHT-, LRR- and PYD-Containing Protein 1, DEFCAP, NAC, CARD7, Caspase Recruitment Domai"
NALP1 is a 160-170kD member of the NLRP family of molecules. It is expressed in dendritic cells, neutrophils, T and B cells, alveolar macrophages, permatogonia, neurons, plus intestinal columnar epithelium, and is found in both cytoplasm and nucleus. NALP1 promotes apoptosis plus IL-1b and IL-18 maturation by activating caspase-1 and -5. It does so by forming a 700kD inflammasome comprised of NALP1, ASC plus caspase-1 and -5. Bacterial wall peptidoglycan binds to NALP1, promoting ATP binding, NALP1 oligomerization, and caspase activation. Human NALP1 is 1473aa in length. It contains an N-terminal DAPIN domain (aa1-92), a NACHT domain (aa328-637), seven consecutive LRRs (aa704-1236) and one CARD region (aa1374-1463). Alternate splice forms exist that range in size from 70-150kD. Either individually, or in combination, there can be a 19aa substitution for either aa1353-1473 or aa1368-1472, a deletion of aa91-260, 958-987, 1262-1305, and a 43aa insert after aa785. Over aa1-323, human NALP1 shares less than 20aa identity with mouse NALP1. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-NLRP1, Anti-NACHT, LRR and PYD domains-containing protein 1, Anti-Caspase recruitment domain-containing protein 7, Anti-Nucleotide-binding domain and caspase recruitment domain, Anti-Death effector filament-forming ced-4-like apoptosis protein |
Supplier: | United States Biological |
Supplier-Nr: | N0018-60J1 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Sheep |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to aa1-323 (aa155) from human NALP1 expressed in E. coli (Q9C000). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K12798 | Matching products |
UniProt ID : | Q9C000 | Matching products |
Gene ID | GeneID 22861 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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