Anti-NALP1 (NACHT-, LRR- and PYD-Containing Protein 1, DEFCAP, NAC, CARD7, Caspase Recruitment Domai

Anti-NALP1 (NACHT-, LRR- and PYD-Containing Protein 1, DEFCAP, NAC, CARD7, Caspase Recruitment Domai
Item number Size Datasheet Manual SDS Delivery time Quantity Price
N0018-60L.50 50 µl - -

3 - 19 business days*

490.00€
 
NALP1 (also known as NAC:CARD7) is a member of the CATERPILLER (CLR) diverse multigene... more
Product information "Anti-NALP1 (NACHT-, LRR- and PYD-Containing Protein 1, DEFCAP, NAC, CARD7, Caspase Recruitment Domai"
NALP1 (also known as NAC:CARD7) is a member of the CATERPILLER (CLR) diverse multigene superfamily of immune regulatory proteins (Ting andDvis, 2005). CLR proteins have a variable N-terminal domain, followed by a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). The N-terminal domain consists of transactivation, CARD, Pyrin or BIR domains, or in some cases is undefined. The CLR family, also known as the NOD family, has its ancient roots in the plant kingdom and is related to the disease resistance (R) gene family that mediates plant immune responses. CLR proteins participate in both innate and adaptive immunity in mammals, some act as sensors that detect pathogen products, and several CLR genes have been linked to susceptibility to immunological diseases. It is thought that the CLR family may have a fundamental importance for the function of the mammalian innate:ancient immune system on par with the Toll-like receptor (TLR) family. NALP1, a member of NALP CLR subfamily, has an N-terminal pyrin domain (PYD), followed by an NBD, LRR, and a C-terminal CARD domain (reviewed in Tschopp. NALP1 is a component of both the inflammasome and apoptosome, suggesting that NALP1 it has important roles in both inflammation and apoptosis. Recognizes NALP1, human NALP1 is a 1473aa protein and migrates at ~166kD on SDS-PAGE. However, multiple splice variants encoding distinct NALP1 isoforms with varying aa lengths have been described and thus the molecular weight detected may vary depending on the isoform(s) expressed. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000, Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000, Immunoprecipitation: 1:50-1:200, Immunohistochemistry: Frozen, Optimal dilutions to be determined by the researcher. Positive Control: Brain, lymphoid, many cancer cell lines, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-NLRP1, Anti-NACHT, LRR and PYD domains-containing protein 1, Anti-Caspase recruitment domain-containing protein 7, Anti-Nucleotide-binding domain and caspase recruitment domain, Anti-Death effector filament-forming ced-4-like apoptosis protein
Supplier: United States Biological
Supplier-Nr: N0018-60L

Properties

Application: IHC, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic peptide corresponding to aa1058-1077 (CVPSPASQGDLHTKPLGTDD) of human NALP1 (NAC/CARD7), GenBank no. NP_127497.1.
Format: Serum

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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