Anti-MYLIP / IDOL

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG42116.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent... more

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Product information "Anti-MYLIP / IDOL"

Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. [The UniProt Consortium]

Keywords:	Anti-MIR, Anti-Idol, Anti-BZF1, Anti-MYLIP, Anti-BM-023, EC=2.3.2.27, Anti-E3 ubiquitin-protein ligase MYLIP, Anti-Inducible degrader of the LDL-receptor, Anti-RING-type E3 ubiquitin transferase MYLIP
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG42116

Properties

Application:	IHC (paraffin), WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant fusion protein corresponding to aa. 266-445 of Human MYLIP / IDOL (NP_037394.2)
MW:	50 kD
Format:	Affinity Purified