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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V4160-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V4160-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Mucins are a group of... more
Product information "Anti-MUC5AC, clone MUC5AC/7798R"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAcAlpha1- 4Galbeta-R structures, indicating that Alpha1, 4-N acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppresses its expression. Additionally, asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNFAlpha stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol-dependent, and RA control of mucin genes is mediated by the retinoid acid receptor RARAlpha and, to a lesser extent, by RARGamma. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small intestine, gastric cells (Lewis type 1) and gastric metaplasia and it is one of the major mucins in the ethmoid mucosa. Protein function: Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system (PubMed:14535999, PubMed:14718370). Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD) (PubMed:14535999). [The UniProt Consortium]
Keywords: | Anti-TBM, Anti-MUC-5AC, Anti-Mucin-5AC, Anti-Gastric mucin, Anti-Tracheobronchial mucin, Anti-Major airway glycoprotein, Anti-Mucin-5 subtype AC, tracheobronchial, MUC5AC Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V4160 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | MUC5AC/7798R |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Recombinant full-length human MUC5AC protein |
Format: | Purified |
Database Information
KEGG ID : | K13908 | Matching products |
UniProt ID : | P98088 | Matching products |
Gene ID | GeneID 4586 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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