Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
%
Discount Promotion
Promotion:
Receive 15% Discount on Pan-Cancer Markers from Atlas Antibodies!
*1
*1 Offer expires 31/08/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ATA-AMAb91892.100 | 100 µl | - |
7 - 10 business days* |
15 %
|
358.00€
304.30€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DNA mismatch repair protein Msh2 - Protein function: Component of the post-replicative DNA... more
Product information "Anti-MSH2, clone CL13724"
DNA mismatch repair protein Msh2 - Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containing DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. [The UniProt Consortium] Enhanced validation: Yes. Concentration: 0.7 mg/ml. Immunogen homology (mouse/rat): ENSMUSG00000024151: 95%, ENSRNOG00000015796: 90%. Buffer formulation: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Keywords: | Anti-MSH2, Anti-hMSH2, Anti-MutS protein homolog 2, Anti-DNA mismatch repair protein Msh2 |
Supplier: | Atlas Antibodies |
Supplier-Nr: | AMAb91892 |
Properties
Application: | ICC |
Antibody Type: | Monoclonal |
Clone: | CL13724 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Format: | Solution |
Database Information
KEGG ID : | K08735 | Matching products |
UniProt ID : | P43246 | Matching products |
Gene ID | GeneID 4436 | Matching products |
Handling & Safety
Storage: | +4°C (-20 °C for long term storage) |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed