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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-36-2800-20 | 20 µg | - |
3 - 11 business days* |
375.00€
|
|||
ABE-36-2800-100 | 100 µg | - |
3 - 11 business days* |
853.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The two members of the large family of ABC transporters known to confer multidrµg resistance in... more
Product information "Anti-MRP1 / ABCC1 (Multidrµg Resistance Related Protein 1) Monoclonal Antibody (Clone: MRP1/1344)"
The two members of the large family of ABC transporters known to confer multidrµg resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrµg-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. Protein function: Mediates export of organic anions and drugs from the cytoplasm (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17- beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed:7961706, PubMed:16230346, PubMed:9281595, PubMed:10064732, PubMed:11114332). Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed:9281595). Hydrolyzes ATP with low efficiency (PubMed:16230346). Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed:17050692). Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. [The UniProt Consortium]
Keywords: | Anti-MRP, Anti-LTC4 transporter, Anti-Leukotriene C(4) transporter, Anti-Multidrug resistance-associated protein 1, Anti-ATP-binding cassette sub-family C member 1, Anti-Glutathione-S-conjugate-translocating ATPase ABCC1, Anti-MRP1 / ABCC1 (Multidrµg Resi |
Supplier: | Abeomics |
Supplier-Nr: | 36-2800 |
Properties
Application: | FC, IF |
Antibody Type: | Monoclonal |
Clone: | MRP1/1344 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant full-length human ABCC1 protein |
Database Information
KEGG ID : | K05665 | Matching products |
UniProt ID : | P33527 | Matching products |
Gene ID | GeneID 4363 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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