Anti-Mouse Perforin, Elab Fluor(R) 647 conjugated, clone S16009A

Perforin is a 70 kD cytolytic protein that is expressed in the cytoplasmic granules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Perforin is one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Protein function: Pore-forming protein that plays a key role in granzyme- mediated programmed cell death, and in defense against virus-infected or neoplastic cells (PubMed:19446473, PubMed:21037563, PubMed:3261391, PubMed:7526382, PubMed:8164737, PubMed:26306037, PubMed:35148176, PubMed:35705808). Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (PubMed:19446473, PubMed:21037563, PubMed:3261391, PubMed:7526382, PubMed:8164737, PubMed:26306037, PubMed:35148176, PubMed:35705808). Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes (PubMed:19446473, PubMed:21037563, PubMed:3261391, PubMed:7526382, PubMed:8164737, PubMed:26306037, PubMed:35148176). Perforin pores allow the release of mature caspase-7 (CASP7) into the extracellular milieu (PubMed:35705808). [The UniProt Consortium]