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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-45-1094-40 | 40 µg | - |
3 - 11 business days* |
499.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
OX40 (CD134, TNFRSF4) is a T cell co-stimulatory molecule of the TNF receptor superfamily that... more
Product information "Anti-Mouse Monoclonal Antibody to Human OX40 (Clone: OX.E12)"
OX40 (CD134, TNFRSF4) is a T cell co-stimulatory molecule of the TNF receptor superfamily that coordinates with other co-stimulators (CD28, CD40, CD30, CD27 and 4-1BB) to manage the activation of the immune response. OX40 is up-regulated on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. OX40 Ligand is primarily expressed on antigen presenting cells. OX40 Ligand engagement of OX40 on activated CD4+ T cells results in increased T cell survival, proliferation, and cytokine production. It also inhibits the conversion of effector T cells into immunosuppressive regulatory T cells (Tregs) and can promote the maintenance of and recall response in memory T cells. OX40 is constitutively expressed on Tregs and enhances the sensitivity of Tregs to IL-2, thus promoting Treg proliferation. OX40 has also been shown to decrease the cells' immunosuppressive activity on effector T cells. OX40-OX40 Ligand signaling is involved in allergic airway inflammation, graft-versus-host disease and autoimmune disease. Mutations in OX40 and OX40 Ligand are associated with cardiovascular disease. Human OX40 Antibody (OX.E12), mAb, Mouse is produced from a hybridoma resulting from the fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with recombinant human OX40-His.
Supplier: | Abeomics |
Supplier-Nr: | 45-1094 |
Properties
Application: | ELISA |
Antibody Type: | Monoclonal |
Clone: | OX.E12 |
Conjugate: | No |
Host: | Mouse |
Immunogen: | Recombinant human OX40-His |
Format: | Purified |
Database Information
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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