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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-F1036B.25 | 25 µg | - |
7 - 16 business days* |
30.00€
|
|||
E-AB-F1036B.100 | 100 µg | - |
7 - 16 business days* |
67.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD210 is a 90-110 kD IL-10 receptor. It is a class II cytokine receptor expressed on thymocytes,... more
Product information "Anti-Mouse CD210, Biotin conjugated, clone 1B1.3A"
CD210 is a 90-110 kD IL-10 receptor. It is a class II cytokine receptor expressed on thymocytes, T cells, B cells, NK cells, monocytes and macrophages. Ligand binding of CD210 induces Jak1 and Tyk, resulting in STAT1 and STAT3 activation. IL-10 receptor stimulation results in the inhibition of cytokine production and the costimulation of B cell proliferation and differentiation. The only known ligand for this receptor is IL-10. Protein function: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3 (PubMed:8910398). Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy. [The UniProt Consortium]
Keywords: | Anti-Il10r, Anti-CD210, Anti-Il10ra, Anti-CDw210a, Anti-IL-10R1, Anti-IL-10RA, Anti-IL-10R subunit 1, Anti-IL-10R subunit alpha, Anti-IL-10 receptor subunit alpha, Anti-Interleukin-10 receptor subunit 1, Anti-Interleukin-10 receptor subunit alpha, Biotin |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-F1036B |
Properties
Application: | FC, FC (membrane) |
Antibody Type: | Monoclonal |
Clone: | 1B1.3A |
Conjugate: | Biotin |
Host: | Rat |
Species reactivity: | mouse |
Database Information
KEGG ID : | K05134 | Matching products |
UniProt ID : | Q61727 | Matching products |
Gene ID | GeneID 16154 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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