Anti-Mouse CD172a (SIRP alpha) NALE(TM) Purified (Clone: P84)

The P84 monoclonal antibody specifically reacts with mouse CD172a, a type I transmembrane protein otherwise known as the signal-regulatory protein alpha. It is an adhesion molecules expressed on dendritic cells, monocytes, macrophages, and neuronal tissue. It is reported to be involved in regulating the phagocytic activity of macrophages and mediating neural synaptic activity. The P84 antibody is reported to have neutralizing capability. Protein function: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. [The UniProt Consortium]