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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
E-AB-F1090L.200 | 200 tests | - |
7 - 16 business days* |
420.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD103 is a type I transmembrane glycoprotein known as alphaE integrin or Integrin alphaIEL chain.... more
Product information "Anti-Mouse CD103, Elab Fluor(R) 488 conjugated, clone M290"
CD103 is a type I transmembrane glycoprotein known as alphaE integrin or Integrin alphaIEL chain. It belongs to the integrin family and is primarily found on intestinal intraepithelial lymphocytes (IEL). CD103 is also expressed on a subpopulation of lamina propria T cells, epithelial dendritic cells, lamina propria-derived dendritic cells, and a small subset of peripheral lymphocytes. T regulatory cells express high level of CD103. The CD103 expression on lymphocytes can be induced upon activation and TGF-beta stimulation. In association with integrin beta7, CD103 is expressed as alphaE/beta7 heterodimer. Mature CD103 protein can be cleaved into 2 chains, a 150 kD (C-terminal) chain and a 25 kD (N-terminal) chain, which remain linked by disulfide bonds. CD103 binds to E-cadherin and mediates homing of lymphocytes to the intestinal epithelium. Protein function: Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall. [The UniProt Consortium]
Keywords: | Anti-Itgae, Elab Fluor(R) 488 Anti-Mouse CD103 Antibody[M290] |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-F1090L |
Properties
Application: | FC, FC (membrane) |
Antibody Type: | Monoclonal |
Clone: | M290 |
Conjugate: | EF488 |
Host: | Rat |
Species reactivity: | mouse |
Database Information
KEGG ID : | K06524 | Matching products |
UniProt ID : | Q60677 | Matching products |
Gene ID | GeneID 16407 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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