Anti-MLL5

Anti-MLL5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F40100-0.08ML 80 µl - -

3 - 10 business days*

326.00€
NSJ-F40100-0.4ML 400 µl - -

3 - 10 business days*

702.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene is a member of the myeloid/lymphoid or... more
Product information "Anti-MLL5"
In 1X PBS, pH 7.4, with 0.09% sodium azide. This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq]. Protein function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. [The UniProt Consortium]
Keywords: Anti-MLL5, Anti-KMT2E, EC=2.1.1.43, Anti-Lysine N-methyltransferase 2E, Anti-Histone-lysine N-methyltransferase 2E, Anti-Myeloid/lymphoid or mixed-lineage leukemia protein 5, MLL5 Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: F40100

Properties

Application: WB, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A portion of amino acids 93-120 from the human protein was used as the immunogen for this MLL5 antibody.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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