Anti-MELK

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-136A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-136A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Serine/threonine-protein kinase involved in various processes such as cell... more

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Product information "Anti-MELK"

Protein function: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. [The UniProt Consortium]

Keywords:	Anti-MELK, Anti-hMELK, Anti-hPK38, Anti-KIAA0175, Anti-pEg3 kinase, EC=2.7.11.1, EC=2.7.10.2, Anti-Protein kinase Eg3, Anti-Protein kinase PK38, Anti-Tyrosine-protein kinase MELK, Anti-Maternal embryonic leucine zipper kinase
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-136A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: horse, orangutan, rhesus monkey, gorilla, chimpanzee, white-tufted-ear marmoset, crab-eating macaque, naked mole rat, thirteen-lined ground squirrel, little brown bat, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A303-136A-T maps to a region between residue 425 and 475 of human Maternal Embryonic Leucine Zipper Kinase using the numbering given in entry NP_055606.1 (GeneID 9833).
Format:	Antigen Affinity Purified