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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES6230.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES6230.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade... more
Product information "Anti-MEK Kinase-4"
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 Protein function: Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. [The UniProt Consortium] Recommended dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.. Cellular localization: Cytoplasm, perinuclear region . Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. .
Keywords: | Anti-MAP3K4, Anti-MEKK 4, Anti-KIAA0213, Anti-MEK kinase 4, EC=2.7.11.25, Anti-MAP three kinase 1, Anti-MAPK/ERK kinase kinase 4, Anti-Mitogen-activated protein kinase kinase kinase 4, MEK Kinase-4 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES6230 |
Properties
Application: | IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | The antiserum was produced against synthesized peptide derived from human MAP3K4. AA range:1281-1330 |
Format: | Antiserum |
Database Information
KEGG ID : | K04428 | Matching products |
UniProt ID : | Q9Y6R4 | Matching products |
Gene ID | GeneID 4216 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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