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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The activation of gene transcription is a multistep process that is triggered by factors that... more
Product information "Anti-MED1"
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. Protein function: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1- mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). [The UniProt Consortium]
Keywords: | Anti-PBP, Anti-MED1, Anti-TRIP-2, Anti-ARC205, Anti-Trap220, Anti-PPAR-binding protein, Anti-TR-interacting protein 2, Anti-Mediator complex subunit 1, Anti-p53 regulatory protein RB18A, Anti-Thyroid receptor-interacting protein 2, MED1 Polyclonal Antibod |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-67088 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant fusion protein of human MED1 (NP_004765.2). |
Database Information
KEGG ID : | K15144 | Matching products |
UniProt ID : | Q15648 | Matching products |
Gene ID | GeneID 5469 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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