Anti-MCL1 (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1, Bcl-2-like Protein 3, Bcl2-L

Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins. It has a pro-survival role in the early stages of apoptosis, and is thought to prevent cytochrome c release from mitochondria. Mcl-1 is also essential for embryogenesis and for the development and maintenance of B and T lymphocytes. Mcl-1 is a highly regulated protein induced by a wide range of survival signals, including cytokines and growth factors. During apoptosis, Mcl-1 is rapidly degraded by the proteasome pathway, and is also readily cleaved by caspases to produce a potent cell death promoting protein. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml, Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.