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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ4821 | 100 µl | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. DNA methylation is... more
Product information "Anti-MBD3, clone AFEE-13"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. The MBD3 gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. [RefSeq] Protein function: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:12124384, PubMed:16428440, PubMed:28977666). Acts as transcriptional repressor and plays a role in gene silencing (PubMed:10947852, PubMed:18644863). Does not bind to methylated DNA by itself (PubMed:12124384, PubMed:16428440). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases. [The UniProt Consortium]
Keywords: | Anti-MBD3, Anti-Methyl-CpG-binding protein MBD3, Anti-Methyl-CpG-binding domain protein 3, MBD3 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ4821 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | AFEE-13 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A synthetic peptide specific to human MBD3 |
Format: | Purified |
Database Information
KEGG ID : | K11591 | Matching products |
UniProt ID : | O95983 | Matching products |
Gene ID | GeneID 53615 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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