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Promotion:
Get 15% Discount on Antibodies and Biosimilars by Abeomics!
*1
*1 Offer expires 30/06/2024
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Discount | Price |
---|---|---|---|---|---|---|---|---|
ABE-10-7007-F-100 | 100 µg | - |
3 - 11 business days* |
15 %
|
418.00€
355.30€ |
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
MBD1 (Methyl-CpG-Binding Domain Protein 1) protein is a primary candidate for the readout of DNA... more
Product information "Anti-MBD1 (Clone: ABM15H2) FITC Conjugated"
MBD1 (Methyl-CpG-Binding Domain Protein 1) protein is a primary candidate for the readout of DNA methylation as it recruits chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. This protein, a member of a transcriptional repressor family MBD, is predominantly expressed in neurons. MBD protein binding requires both functional MBD domains and methyl-CpGs, however, some MBD proteins also bind unmethylated DNA and active regulatory regions via alternative regulatory domains or interaction with the NuRD/Mi-2 (Nucleosome Remodeling Deacetylase) complex members. The CXXC3 domain of MBD1 makes it a unique member of the MBD family due to its affinity to unmethylated DNA. MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex. It also plays an important role in disease progression, contributes to the drug resistance of PC cells, however, the mechanism underlying the drug resistance endowed by MBD1 remains unknown. Protein function: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. [The UniProt Consortium]
Keywords: | Anti-MBD1, Anti-CXXC3, Anti-Methyl-CpG-binding protein MBD1, Anti-CXXC-type zinc finger protein 3, Anti-Methyl-CpG-binding domain protein 1, Anti-Protein containing methyl-CpG-binding domain 1, Monoclonal Antibody to MBD1 (Clone: ABM15H2) FITC Conjugated |
Supplier: | Abeomics |
Supplier-Nr: | 10-7007-F |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | ABM15H2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A partial length recombinant MBD1 protein (amino acids 291-586) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K11589 | Matching products |
UniProt ID : | Q9UIS9 | Matching products |
Gene ID | GeneID 4152 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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