Anti-MBD1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA068850.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA068850.100	100 µl		-		7 - 10 business days*		446.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Transcriptional repressor that binds CpG islands in promoters where the DNA is... more

Close menu

Product information "Anti-MBD1"

Protein function: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 68% and to rat: 66%

Keywords:	Anti-CXXC3, Anti-CXXC-type zinc finger protein 3, Anti-Methyl-CpG-binding protein MBD1, Anti-Methyl-CpG-binding domain protein 1, Anti-Protein containing methyl-CpG-binding domain 1
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA068850

Properties

Application:	ICC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PGCPSKAVDP GLPSVKQEPP DPEEDKEENK DDSASKLAPE EEAGGAGTPV ITEIFSLGGT RFRDTAVWLP RSK (ATA-APrEST94311)