Anti-MBD1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG41998.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Transcriptional repressor that binds CpG islands in promoters where the DNA is... more

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Product information "Anti-MBD1"

Protein function: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. [The UniProt Consortium]

Keywords:	Anti-MBD1, Anti-CXXC3, Anti-CXXC-type zinc finger protein 3, Anti-Methyl-CpG-binding protein MBD1, Anti-Methyl-CpG-binding domain protein 1, Anti-Protein containing methyl-CpG-binding domain 1
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41998

Properties

Application:	ICC, IF, IHC (paraffin), IP, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Synthetic peptide of Human MBD1
MW:	67 kD
Format:	Affinity Purified