Anti-MAVS/VISA

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-782A-T	10 µl (2 µg)		-		2 - 8 business days*		164.00€
A300-782A	100 µl		-		2 - 8 business days*		588.00€

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Protein function: Required for innate immune defense against viruses. Acts downstream of... more

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Product information "Anti-MAVS/VISA"

Protein function: Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. [The UniProt Consortium]

Keywords:	Anti-VISA, Anti-MAVS, Anti-IPS1, Anti-IPS-1, Anti-Cardif, Anti-Virus-induced-signaling adapter, Anti-CARD adapter inducing interferon beta, Anti-Mitochondrial antiviral-signaling protein, Anti-Putative NF-kappa-B-activating protein 031N
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-782A

Properties

Application:	WB, IP, IHC, ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: chimpanzee)
Immunogen:	synthetic peptide. The epitope recognized by A300-782A-T maps to a region between residue 150 and 200 of human Mitochondrial Anti-Viral Signaling Protein (Virus-Induced Signaling Adapter) using the numbering given in entry AAH44952.1 (GeneID 57506).
Format:	Antigen Affinity Purified