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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
M2429-03A.100 | 100 µg | - | - |
3 - 19 business days* |
886.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases.... more
Product information "Anti-Matrix Metalloproteinase 14 (MT1-MMP, MMP-14, Collagenase-3)"
Matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes degrade the components of extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. MMPs play an important role in wound healing, apoptosis, bone elongation, embryo development, angiogenesis, cancer metastases, and tissue remodeling within many disease states. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MT1-MMP (MMP-14) is a member of the membrane-type subfamily. Each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of extracellular matrix components and is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix. This protein also activates MMP2 protein, and this activity may be involved in tumor invasion. , Applications: , Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2ug/ml, Immunohistochemistry (paraffin): 1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-MMP14, Anti-MMP-X1, Anti-MT1MMP, Anti-MTMMP1, EC=3.4.24.80, Anti-MT-MMP 1, Anti-Matrix metalloproteinase-14, Anti-Membrane-type-1 matrix metalloproteinase, Anti-Membrane-type matrix metalloproteinase 1 |
Supplier: | United States Biological |
Supplier-Nr: | M2429-03A |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat |
Immunogen: | Synthetic peptide selected from the hinge region of human MT1-MMP (KLH). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K07763 | Matching products |
UniProt ID : | P50281 | Matching products |
Gene ID | GeneID 4323 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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