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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
M2352-10B.100 | 100 µl | - | - |
3 - 19 business days* |
819.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine... more
Product information "Anti-MAP Kinase p44/42, (Erk1/2) (MAPK, Erk1/2, Extracellular Signal Regulated Kinase 1/2) (Alexa Fl"
Mitogen-activated protein kinases (MAPKs) are a widely conserved family of serine/threonine protein kinases involved in many cellular programs such as cell proliferation, differentiation, motility, and death. The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli including mitogens, growth factors, and cytokines (1-3) and is an important target in the diagnosis and treatment of cancer (4). Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family as well as Mos and Tpl2/Cot. MEK1 and MEK2 are the primary MAPKKs in this pathway (5,6). MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK (7) and the transcription factor Elk-1 (8,9). p44/42 are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs (10), along with MEK inhibitors such as U0126 and PD98059. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4°C. Freezing Alexa Fluor(R) conjugates will result in a substantial loss of activity. Alexa Fluor(R) conjugates are sensitive to light.
Keywords: | Anti-ERT2, Anti-MAPK3, Anti-ERK-1, Anti-MAPK 3, Anti-MAPK 1, EC=2.7.11.24, Anti-p44-ERK1, Anti-p44-MAPK, Anti-MAP kinase 1, Anti-MAP kinase 3, Anti-MAP kinase isoform p44, Anti-Insulin-stimulated MAP2 kinase, Anti-Mitogen-activated protein kinase 3 |
Supplier: | United States Biological |
Supplier-Nr: | M2352-10B |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | 10E37(137F5) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | bovine, C.elegans, hamster, human, monkey, mouse, swine, rat, zebrafish |
Immunogen: | A synthetic peptide (KLH-coupled) corresponding to residues near the carboxy terminus of rat p44 MAP kinase. |
Format: | Supernatant |
Database Information
KEGG ID : | K04371 | Matching products |
UniProt ID : | P27361 | Matching products |
Gene ID | GeneID 5595 | Matching products |
Handling & Safety
Storage: | +4°C (do not freeze) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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