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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3042-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V3042-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of... more
Product information "Anti-Major Vault Protein (MVP), clone 1014"
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Protein function: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. [The UniProt Consortium]
Keywords: | Anti-MVP, Anti-LRP, Anti-Major vault protein, Anti-Lung resistance-related protein, Major Vault Protein Antibody (MVP) |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3042 |
Properties
Application: | WB, FC, IF |
Antibody Type: | Monoclonal |
Clone: | 1014 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Proteins precipitated from human breast cancer MCF-7 cells |
Format: | Purified |
Database Information
KEGG ID : | K17266 | Matching products |
UniProt ID : | Q14764 | Matching products |
Gene ID | GeneID 9961 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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