Anti-Major Vault Protein (MVP), clone SPM280

Anti-Major Vault Protein (MVP), clone SPM280
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3044IHC-7ML 7 ml - -

3 - 10 business days

541.00€
 
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*.... more
Product information "Anti-Major Vault Protein (MVP), clone SPM280"
Prediluted in 1X PBS, 0.1 mg/ml BSA (US sourced), 0.05% sodium azide, *For IHC use only*. Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy. Protein function: Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. [The UniProt Consortium]
Keywords: Anti-MVP, Anti-LRP, Anti-Major vault protein, Anti-Lung resistance-related protein, Major Vault Protein Antibody (MVP)
Supplier: NSJ Bioreagents
Supplier-Nr: V3044IHC-7ML

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: SPM280
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: Proteins precipitated from human breast cancer MCF-7 cells
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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